Formerly The King's Yard, the first of the Royal Dockyards which was built by Henry VIII in 1513, Convoys Wharf has been derelict for over a decade.
An application to build up to 3,500 new homes on the site was submitted to Lewisham Council earlier this year but the application expired without resolution.
The developer then asked the the Mayor to take over as planning authority for the project, which he has agreed to do.
Boris Johnson, said:
“We need to build thousands of new homes in the capital and proposals to do that at Convoys Wharf have been on the blocks for over a decade.
Those plans deserve full and thorough consideration, and my team will work closely with the Borough and the applicant to do so without further delay.”