Vincenzo has been transformed from a patient so sick he could not wash his face to a man who strides confidently with a gleam in his eye.
Alex Smith was diagnosed with a heart problem but after receiving a transplant he feels he has been given the "greatest gift of life."
While 90% of people believe donating an organ is the right thing to do - only 30% are signed up to the organ donor register.
Ria Chatterjee runs through the statistics on organ donation in London.
ITV's From The Heart campaign is trying to encourage more people to sign up to the organ donor register and ultimately, help save lives.
ITV News London has today had exclusive access to the Royal London hospital in Whitechapel, where around 80 transplants are carried out each year, and a very special one happened just last night.
Ria Chatterjee has spent the day at that hospital.
All week we've been telling you about ITV's From The Heart campaign to try and encourage more people to sign up to the organ donor register.
ITV News London has today had exclusive access to the Royal London Hospital in Whitechapel, where around 80 transplants are carried out each year.
From there, Ria Chatterjee reports.
Two people die every week while waiting for a transplant in and around London. Right now, there are 2,000 people on the transplant waiting list.
As part of ITV's From The Heart campaign, Our reporter Ria Chatterjee went to meet one of those waiting for a transplant, 17-year-old Sophie Washington.
ITV's 'From the Heart' campaign encourages the public to sign up to the organ donor register to help patients currently waiting for a donation. You can find out how to join the register by clicking here:
Why join the register? There are more people who have signed up than you might think.
In London and its surrounding regions, there are 4.3million people on the list but, they are always in need of more to increase the chances of helping the 2,000 patients waiting for a transplant.
Whilst great work is being done and live are being saved, there are still people dying. Last year from April to January, 864 patients got the organ they needed. Sadly it was not enough for some and over 60 people died whilst waiting.
There is a desperate shortage of organ donors in the UK which is is why ITV has launched the From the Heart campaign to help save more lives.
ITV's From the Heart campaign is taking place in Valentine's Week to raise awareness of organ donation and the NHS Organ Donor Register.
We're highlighting the shortage of donated organs in the UK, and encouraging viewers to join the register, and to talk to their loved ones about their wishes.
Daybreak, This Morning, and Tonight will support the campaign, exploring the shortage of donated organs, and how lives can be transformed
.At 9pm on Feb 13th, ITV brings together a host of stars for a one-hour special featuring musical and comedy treats from the likes of Rowan Atkinson, Hugh Laurie, Pixie Lott, Harry Enfield and Paul Whitehouse - don't miss it!
To join the organ donation register visit www.itv.com/fromtheheart