Transport Secretary Chris Grayling has said building a third runway at Heathrow is the "clearest sign that this country is open for business" after the referendum.
He told ITV News Deputy Political Editor Chris Ship the Government's announcement was a "really big decision for this country".
We've thought long and hard about this. There were three very good options on the table but we believe a third runway at Heathrow is the best option for our future, it's the best for the whole country - it's going to create better connectivity to the different regions of the United Kingdom - and to provide the best trade links to the world.
Asked why the whole Cabinet couldn't support the project, Mr Grayling said: "It would be impossible to deliver a project like this without some people disagreeing with the strategy."
He said the third runway would "absolutely" be built.
The Government has confirmed it has chosen to build a third runway at Heathrow Airport as its preferred airport expansion project.
The Department for Transport announced the £17.6 billion project after a Cabinet meeting of the airport sub-committee chaired by Prime Minister Theresa May.
The other shortlisted options - to extend an existing runway at Heathrow or build a second runway at Gatwick - were rejected in favour of a decision that will see more than 780 homes demolished in west London.
Fierce opponents of Heathrow expansion within Cabinet, Foreign Secretary Boris Johnson and Education Secretary Justine Greening, will both speak out at the decision after being cleared by Mrs May to air their dissent.
The Government announcement ends more than a year of uncertainty since the Davies Commission came out in favour of Heathrow's third runway.
A public consultation will be held on the impact of the expansion before the final decision is put to MPs for a vote in the winter of 2017/18, with the runway unlikely to be in use before 2025.
Protests have been held at Westminster as the Government prepares to announce its long-awaited decision on airport expansion.
Transport Secretary Chris Grayling is expected to confirm plans for a third runway at Heathrow after a Cabinet meeting.
The Government is to choose which scheme to back after a review of the UK's airport capacity. Here are the three shortlisted options.Read the full story ›
The Government's long-awaited decision on which scheme - Heathrow or Gatwick - should get the go-ahead will finally be announced later.Read the full story ›
Reclaim the Power stage a protest at Heathrow against a new runway or further airport expansion.Read the full story ›
An internal Government document has revealed details on how ministers could be given a free vote on whether to expand Heathrow Airport.Read the full story ›
A cross-party group of eleven councils across the capital have urged Theresa May to back Gatwick's bid to build London's new runway.Read the full story ›
The leaders of 34 locals authorities across Britain have written a letter to the Transport Secretary backing expansion at Heathrow.Read the full story ›