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Rail users have been urged to avoid London Bridge or expect heavy delays after a pothole under a track caused travel chaos.
Emergency repair works at Forest Hill, the second such incident in a month, caused Thameslink, Southern and London Overground services in south-east London to be delayed or cancelled on Thursday morning.
Southern services are not stopping at number of stations, including: Norwood Junction, Anerley, Penge West, Sydenham, Forest Hill, Honor Oak Park, Brockley, and New Cross Gate.
Commuters were initially warned the disruption could last until 6pm, but have now been told it will last the rest of the day.
Robert Coulson, Network Rail acting director, said engineers would be continuing to fix the problem for the remainder of Thursday.
"I’m really sorry that passengers have had to put up with this disruption today and I know that people are upset and will want to know we are doing everything we can to return their railway to them", he said.
Passengers are advised to use either Victoria or Blackfriars tonight.
Southern tickets are being accepted on London Buses, London Underground, Southeastern and Tramlink between Beckenham Junction and Croydon.
Network Rail and Thameslink bosses face the London Assembly's Transport Committee later.
Rail executives will be questioned over recent overcrowding and chaos at London Bridge station.
Commuters faced weeks of disruption because of reconstruction work at the station.
London Bridge Station has again been struck by rush hour problems, on the day new measures designed to ease commuter congestion were due to come into force.
Train services were affected by signal failures between 4.30pm and 5.30pm but the knock-on effect was due to affect trains until around 7pm, , Network Rail said.
It comes as the station undergoes extensive long-running engineering work which has led to major congestion, including one occasion when police were called to keep order.
Network Rail tweeted: "London Bridge station is extremely busy - please consider using alternatives this evening."
A spokeswoman added that they were advising people to use Victoria instead, saying: "A signal failure outside the station put two of the four lines in to London Bridge out of action between 4.30pm and 5.30pm. We fixed the problem but as with anything like this there is a knock on effect."
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Train services are expected to be disrupted until 9pm tonight, following delays between London Euston / Clapham Junction and Milton Keynes this morning.
Safety checks being made on the line between Hemel Hempstead and Watford Junction mean trains are having to run at a reduced speed between Milton Keynes Central and London Euston / Clapham Junction.
London Midland and Southern railways are no longer affected by this, but Virgin Trains will run a reduced service between Manchester Piccadilly / Birmingham New Street and London Euston.
Passengers may be delayed by up to 20 minutes.