Vincenzo has been transformed from a patient so sick he could not wash his face to a man who strides confidently with a gleam in his eye.
Alex Smith was diagnosed with a heart problem but after receiving a transplant he feels he has been given the "greatest gift of life."
While 90% of people believe donating an organ is the right thing to do - only 30% are signed up to the organ donor register.
A one-year-old baby is recovering from a heart transplant at the Royal Brompton Hospital.
The family of Carina Marcangelo say she is in a critical condition following surgery on Sunday but making steady progress.
Carina had a disease which damages the heart and became the youngest person in Britain to be fitted with a mini-defibrillator.
Carina has cardiomyopathy which damages the heart. She spent her first birthday completely sedated on life support at the Royal Brompton as she awaited a donor organ.
She became the youngest child to be fitted with a mini defibrillator (ICD) in her chest in November at just 9 months old. The device gave her heart a shock if its rhythm worsened.
Carina could only receive a heart from a one-year-old to a small five-year-old. The average waiting time for a heart is around 3 months.
Ria Chatterjee runs through the statistics on organ donation in London.
ITV's From The Heart campaign is trying to encourage more people to sign up to the organ donor register and ultimately, help save lives.
ITV News London has today had exclusive access to the Royal London hospital in Whitechapel, where around 80 transplants are carried out each year, and a very special one happened just last night.
Ria Chatterjee has spent the day at that hospital.
All week we've been telling you about ITV's From The Heart campaign to try and encourage more people to sign up to the organ donor register.
ITV News London has today had exclusive access to the Royal London Hospital in Whitechapel, where around 80 transplants are carried out each year.
From there, Ria Chatterjee reports.
Two people die every week while waiting for a transplant in and around London. Right now, there are 2,000 people on the transplant waiting list.
As part of ITV's From The Heart campaign, Our reporter Ria Chatterjee went to meet one of those waiting for a transplant, 17-year-old Sophie Washington.
ITV's 'From the Heart' campaign encourages the public to sign up to the organ donor register to help patients currently waiting for a donation. You can find out how to join the register by clicking here:
Why join the register? There are more people who have signed up than you might think.
In London and its surrounding regions, there are 4.3million people on the list but, they are always in need of more to increase the chances of helping the 2,000 patients waiting for a transplant.
Whilst great work is being done and live are being saved, there are still people dying. Last year from April to January, 864 patients got the organ they needed. Sadly it was not enough for some and over 60 people died whilst waiting.