St James Street in Piccadilly has been closed due to what is thought to be a lorry fire.
Transport for London has tweeted an update urging drivers to use alternative routes.
BBC journalist Nick Eardley tweeted that the fire appeared to have spread to the lorry after starting underground.
Police closed off part of a road in central London earlier today after a poorly swan touched down. The swan ended up being coned off in a parking bay on Jermyn Street near Piccadilly.
The bird was eventually taken away by the RSPCA, and the road fully reopened.
Before losing 17 stone, Kim Freshwater had a string of health problems including high blood pressure, breathing problems, back and knee pain.
A mother from Hampshire who lost more than half of her bodyweight has been named Slimming World Woman of the Year 2013 at the Ritz Hotel in Piccadilly.
Kim Freshwater tipped the scales at almost 29 stone and wore size 38 dresses before shedding 17st 5lb in less than three years to trim down to a size 10. The 45-year-old, from Havant in Hampshire, was severely overweight for nearly four decades.
Kim decided to get into shape after she missed her son's school awards ceremony for fear of breaking the foldaway chairs.
Fortnum & Mason will open a new stand-alone store in Britain for the first time in its 307-year history today.
The world-famous Piccadilly establishment's new outlet is in the former ticket hall of London's St Pancras International station.