Five fire engines, a fire rescue unit and around 30 firefighters have been called to reports of a fire and explosion in what is believed to be a workshop on Denmark Hill, close to Coldharbour Lane in Camberwell, SE5.
Around half of the ground floor of the building has been damaged. Early reports suggest that one man has been taken to hospital by ambulance.
Firefighters from Brixton, Peckham, Old Kent Road and Lewisham are on the scene. The Met Police and London Ambulance Service are also there.
The Brigade was called at 1417.
More top news
Boris Johnson wants a personal drone to fly across the skies of London and deliver his online shopping.
Police in Harrow have released CCTV footage as part of a reappeal for information about a sexual assault that happened last November.
Members of the RMT union on the Northern Line are planning to walk out on Monday after a driver was sacked for failing a breath test.