Five fire engines, a fire rescue unit and around 30 firefighters have been called to reports of a fire and explosion in what is believed to be a workshop on Denmark Hill, close to Coldharbour Lane in Camberwell, SE5.
Around half of the ground floor of the building has been damaged. Early reports suggest that one man has been taken to hospital by ambulance.
Firefighters from Brixton, Peckham, Old Kent Road and Lewisham are on the scene. The Met Police and London Ambulance Service are also there.
The Brigade was called at 1417.
More top news
Philip Spence bludgeoned the three sisters from the United Arab Emirates in the four-star Cumberland Hotel - leaving them for dead.
A rare dog has been stolen by a man in Surrey who was pretending to want to buy it.
Two people are dead another person is in hospital after London and the South East was battered by the fallout from Hurricane Gonzalo.