A statement from Virgin Atlantic confirmed that flight VS27 from Gatwick to Orlando had returned to the airport and been evacuated.
It said: "Due to a technical problem on board the aircraft, the captain decided as a precautionary measure to immediately evacuate the aircraft.
"Our teams at Gatwick are now looking after our passengers and assisting with their immediate requirements.
"The safety and welfare of our crew and passengers is Virgin Atlantic's top priority."
The airline said the Airbus A330-300 aircraft had 13 crew and 299 passengers on board.
More top news
Mr Charles died in hospital after he was chased by a police officer into a shop in Dalston and restrained.
The Labour mayor will seek a second term in City Hall.
The Apprentice boss tweeted a picture of the sports team, which had been edited to include a picture of handbags and sunglasses.