A London Ambulance Service spokesman said:
"We were called at 8.39am today to reports of a patient taken unwell at London Bridge station.
"We sent two ambulance crews, a single responder in a car, our hazardous area response team and a duty manager.
"Our staff have assessed four patients at the scene who were taken unwell. Three of the patients have been taken to hospital."
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The engineering projects will hamper the plans of many people hoping to take advantage of the four-day weekend.