New figures show 3,426 tuberculosis (TB) cases were reported in London in 2012, accounting for around 40% of cases nationally.
The figures are published in Public Health England's annual "TB in the UK: 2013 report" published today.
Rates of TB have stabilised nationally at around 14 cases per 100,000 since the mid-2000s following an increase in incidence seen in the previous two decades.
However despite efforts to improve prevention, treatment and control, TB incidence in London is at 42 per 100,000, the highest rate of any western European capital.
Public Health England describes the figures as 'worryingly high'.