Alison and Tim Hysom joined Detective Inspector John Delaney at Ilford police station to appeal for the public's help in finding their 15-year-old daughter.
DI Delaney added: "We are taking this matter seriously and a lot of resources, including search teams, have been deployed. We are concerned for her welfare because she is vulnerable, she is suffering from depression and she is just 15.
"It is out of character and there has been no contact from her since the day she went missing."
More top news
Is your street among London's trendiest hotspots?
Some of the best stories from the past week on itv.com/london. Got a story? Email us at firstname.lastname@example.org
This is Gordon Hill. But you may know him by now as the Wealdstone Raider.