Alison and Tim Hysom joined Detective Inspector John Delaney at Ilford police station to appeal for the public's help in finding their 15-year-old daughter.
DI Delaney added: "We are taking this matter seriously and a lot of resources, including search teams, have been deployed. We are concerned for her welfare because she is vulnerable, she is suffering from depression and she is just 15.
"It is out of character and there has been no contact from her since the day she went missing."
More top news
An ITV News journalist worked as a Deliveroo rider to see what it's like - from induction to cycling through traffic and making deliveries.
Sutton United substitute goalkeeper Wayne Shaw has offered his resignation after eating a pie during a match.
Brixton's tribute to David Bowie will be a gravity-defying structure standing three storeys tall.