Football supporters travelling to Arsenal's match against Newcastle United at the Emirates stadium have been told to plan ahead.
Tube services are unlikely to serve the area after the match with workers set to go on strike from 9pm tonight, TfL said.
Arsenal advised fans to walk to King's Cross, St. Pancras International, Liverpool Street and Euston to connect with National Rail and local bus services.
First Capital Connect trains will be operating from Finsbury Park as normal but they are expected to be much busier than normal, a club statement said.
Chelsea's match with Atletico Madrid is also likely to be affected on Wednesday.