Spurs chose to exercise a break clause in Tim Sherwood's 18-month contract to end his tenure as head coach.
“We agreed an 18-month contract with a break clause at the end of the season and we have now exercised that option," chairman Daniel Levy said in a statement.
"On behalf of the Club, I should like to state our thanks for all his efforts during his years with us. We wish him great success in his managerial career."
Levy said the club would now find a new head coach who can "inspire the kind of performances that we associate with" Spurs.
More top news
Scotland Yard recorded 1,235 Islamophobic attacks in the last 12 months, compared with 811 in 2015.
Officers say the child, aged two, was targeted in the Lewisham Shopping Centre.
New figures show London Fire Brigade received 6,820 malicious hoax calls last year, almost twenty a day.