Spurs chose to exercise a break clause in Tim Sherwood's 18-month contract to end his tenure as head coach.
“We agreed an 18-month contract with a break clause at the end of the season and we have now exercised that option," chairman Daniel Levy said in a statement.
"On behalf of the Club, I should like to state our thanks for all his efforts during his years with us. We wish him great success in his managerial career."
Levy said the club would now find a new head coach who can "inspire the kind of performances that we associate with" Spurs.
More top news
A British Transport Police officer said his broken nail amounted to assault but failed to offer any evidence to explain how it happened.
Zac Goldsmith lost his Richmond Park seat in a shock defeat to the Liberal Democrats.
A woman has been jailed for over two years for crashing into a car and killing a man while trying to send a birthday message on Facebook.