Police say two people have been killed following the crash on the M11 motorway in Essex. The accident involved three cars, a lorry and a horse box shortly before 2.15pm. A man has been arrested on suspicion of causing death by dangerous driving.
Two people in a car have died and the driver and passenger in another car have been taken to hospital in Cambridgeshire.
A woman has serious internal injuries and was flown by air ambulance and a man was taken by ambulance with a head injury.
The carriageway is completely blocked and is impassable. The road will remain closed throughout the afternoon and into the evening. Motorists are advised to avoid the area and find alternate routes.
More top news
The former pub chef who brutally raped and murdered teenage model Sally Anne Bowman has admitted raping another woman.
Ministers outlined proposals to ban the sale of new petrol and diesel vehicles from 2049 as part of a new clean air strategy.
His famous 2002 picture on the wall of a Shoreditch shop, Balloon Girl, came top of a list of British art.