Police were called at 11:09hrs on Thursday 5 June to The Shard, St Thomas Street, SE1 after London Fire Brigade were called to reports of a fire at the premises.
Police, London Fire Brigade and London Ambulance Service attended the fire which is beleived to be in the basement of The Shard.
A full evacuation is now underway.
No reported injuries at this time. No arrests. Enquries re cause of fire are ongoing.
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An eyewitness said: "It was very unnerving. It was just after 12pm and there were suddenly police vans and cars everywhere."