Police have issued CCTV images of a man and two younger women they are trying trace following the attacks.
In a statement, the Met Police said: "In the first incident, at approximately 0400hrs, the substance was sprayed at two men outside the Lightbox nightclub in South Lambeth Place, Vauxhall. This followed a verbal exchange between the two men and a group outside the venue.
"Following comments made during the exchange, this incident is being treated as a homophobic hate crime."A short time later, police were made aware of a third man who had also been sprayed in the face with a substance in the vicinity of the nightclub.
More top news
Anthony Birdee from Deptford in south east London tied the English bull terrier, named Muller, to a post in his garden.
A report warned overcrowded streets could lead to a 'Hillsborough scale' tragedy.
Southern got just one star for punctuality, reliability, seat availability, frequency and value for money.