The Seagulls repeated last season's cup heroics by dumping an under-strength Magpies out of the competition with Andrea Orlandi supplying an outstanding opener.The first-half strike was born out of Wayne Bridge's willingness to chase a seemingly lost cause, but it was Orlandi's touch, turn and fine shot that stole the show.
The second was delivered by substitute Will Hoskins, who tucked home David Lopez's defence-splitting pass, as the play-off hopefuls completed a comfortable win.
Newcastle were further frustrated by captain Shola Ameobi's second-half sending off.
Ameobi was deeply unlucky to receive the second yellow from referee Lee Probert and will miss Saturday's match against Norwich. Full coverage of all the FA Cup results at www.itv.com/sport/football