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Kent Police say six people have been seriously injured in the multi-vehicle collision on the A249.
Motorists are advised to avoid the new Sheppey crossing bridge following the incident.
Kent Police was called at about 7.15am on 5th September 2013 to the London-bound carriageway on the Sheppey crossing.
It has been reported there were collisions at the top of the crossing and at the foot of the approach to the crossing. Emergency services are currently at the scene dealing with the incident.
Our reporter David Johns has sent this picture from the scene of the multi-vehicle pile up on the A249.
Kent Fire and Rescue Service have released this update on their response to the A249 crash.
The crash happened on the new Sheppey crossing bridge on the A249 in Kent and there are reports of injuries.
Police were called at about 7.15am to deal with the incident, along with other emergency services.
A Kent Police spokeswoman said visibility was a problem over the bridge, but it was not clear whether that caused the pile-up.
"There have been some injuries but we cannot say at the moment how serious they are," she said.
Motorists are being warned to avoid the area.
The emergency services are dealing with a major crash on Sheppey Crossing this morning, It has been closed in both directions after many cars have been involved in a pile-up in thick fog. It happened on the A249 just before 7.15am
The A249 Sheppey Crossing in both directions is closed due to a multi-vehicle accident between the A2 London Road (Key Street Roundabout) and the B2006 (Bobbing Roundabout).
Police are reporting that possibly up to 30 vehicles are involved in the accident. It is reported to be very foggy in the area. Emergency services are on the scene. A diversion is in place via Kings Ferry Bridge, drivers should follow hollow diamond symbols.
Latest ITV News reports
More than 100 vehicles have been involved in an accident in misty conditions on a bridge and it is believed that there are serious injuries.