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David Cameron said leaving the EU would threaten Britain's "economic and national security".
The Prime Minister said Britain's new deal offered the "best of both worlds", while leaving the EU would be a "leap in the dark".
The Prime Minister is to announce the planned date for an EU referendum following a Cabinet meeting to be held later this morning.
David Cameron is due to outline the details of his EU reform deal to Cabinet members at 10am as he vowed to campaign "heart and soul" to keep the UK in Europe.
The announcement follows 30 hours of negotiations with EU leaders to agree a package of reforms giving Britain "special status".
David Cameron has announced that the EU referendum will take place on Thursday 23 June.
The EU referendum will be "one of the biggest decisions this country will face in our lifetimes", David Cameron has said.
Following a Cabinet meeting, the Prime Minister said the Government position would be to remain in a reformed EU.
He said Cabinet ministers would be free to campaign on either side of the debate and that there would be "many passionate arguments".
"We are approaching one of the biggest decisions this country will face in our lifetimes," Mr Cameron said outside Number 10. "The choice goes to the heart of the kind of country we want to be and the future we want for our children.
"The choice is in your hands, but my recommendation is clear: I believe that Britain will be safer, stronger and better off in a reformed European Union."