The A4144 Abingdon Road is closed due to flooding between Kineton Road and A423 Southern Bypass (Kennington Roundabout).
The Environment Agency has apologised to Oxfordshire residents for failing to issue a flood warning until six hours after they were under water.
Among the flooded were seven properties in the Wendlebury area and another three in Steventon near Abingdon. It happened when a third of a month's rainfall (33mm) fell in one night last week.
The Environment Agency has been forced to apologise to residents for failing to issue a warning until six hours after a village was flooded.
The move comes after seven homes in Wendlebury, near Bicester, were flooded on Thursday at about 2.30am.
A flood alert was not issued by the Environment Agency until 8.30am.
Residents said it was the fifth time since 2001 that the village had flooded and problems started after the M40 and A41 dual carriageway were built.
The latest flood has also raised concerns that proposals for a new link road from the A41 across farmland near the village to Graven Hill will exacerbate the problem.
A man has died after he fell from his mobility scooter into the Thames. The incident happened close to Abingdon Bridge in Abingdon yesterday afternoon. The man in his 70s was pulled from the water and flown by air ambulance to Oxford’s John Radcliffe Hospital. He was pronounced dead at 9pm.