Notts County moved off the bottom with their first win of the season, goals from Joss Labadie and Marcus Haber giving them a 2-0 home win over Tranmere.
County's success saw Gillingham slide to the foot of the table after the winless Gills fell to Gary Jones' ninth minute winner for Bradford at Priestfield Stadium.
Nile Ranger lashed home an 87th minute winner as Swindon left Bristol City still searching for a first win of their own with a 3-2 win at the County Ground. Full match coverage on the ITV Sport website here
Middlesbrough's Tony Mowbray watched his side fight back from the dead against Bournemouth at the Riverside Stadium only to squander their chances of victory.
Two Brett Pitman penalties gave the Cherries a 2-0 lead inside 12 minutes but Kei Kamara and Mustapha Carayol dragged Boro back level.
Grant Leadbitter gave the home side the lead in the 75th minute but a Jonathan Woodgate own goal sealed a point for the visitors seven minutes from time - and to add to Mowbray's woes Rhys Williams was sent off late for a foul on Wes Thomas
Ritchie Humphreys' first goal of the season was enough to maintain Chesterfield's four-point lead at the top of Sky Bet League Two with a hard-fought 1-0 win at Oxford.
Gary Alexander scored both goals for Town, whose day was soured when Michael Jones was sent off late on. Behind the leading trio of teams at the top of table come three sides on nine points in Brentford, Rotherham and the MK Dons.
The day's biggest winners were Swindon who hammered Crewe 5-0 at the County Ground where Ryan Mason, one of four players signed on loan from Spurs over the summer, scored a 25-minute second-half hat-trick.
Nile Ranger started the rout in the 34th minute before another Spurs loanee in Massimo Luongo added the second just prior to the break. The other two matches culminated in 1-1 draws, with Gillingham and Stevenage held at home by Bristol City and Bradford respectively.
Former Crawley boss Steve Evans made a happy return to Broadfield Stadium as his Rotherdam side beat his old team 2-1.Mat Sadler put Crawley ahead after only 14 minutes but Kieran Agard (36) equalised and substitute David Worrall settled the game 13 minutes from time.
Farid El Alagui's last-gasp strike rescued a 1-1 draw for Brentford against Gillingham and denied former Bees boss Martin Allen a first league win of the season after Adebayo Akinfenwa had slotted home from close range in the 40th minute.
Shrewsbury deservedly eased to their first win of the season as they overcame Swindon 2-0 thanks to goals from debutant Adam Reach (nine) and substitute Tom Bradshaw (85).
The Sky Blues, who start the new campaign with a 10-point deduction, had looked to have salvaged a point when second-half goals from Callum Wilson and Franck Moussa saw them cancel out early efforts from Jamie Proctor and Joe Walsh
However, the visitors were left empty-handed when Mike Jones netted an 84th-minute winner for Crawley Town at the Broadfield Stadium in West Sussex.
For a full round-up of all today's action click here for in-depth match coverage from ITV Sport
Both of the south's teams in League Two managed a point this afternoon.
Oxford United drew 1-all at home to Morecambe. Aldershot also managed a 1-all draw away at Rochdale.
Crawley drew 1-1 at home to Stevenage.
Swindon couldn't manage a win either also drawing 1-all at home to Oldham - which keeps them in the play-off position.
AFC Bournemouth were at Colchester and came away with a 1-nil win which lifts the Cherries into an automatic promotion place.
Portsmouth are away to Preston - kick-off was at 5 o'clock.