Former prime ministers have found that not only does life go on after living at Number 10, but in some cases it actually gets better.
The most recent men to vacate office have shown it can certainly be very lucrative.
Tony Blair made millions from his autobiography and for eight years represented the US, Russia, the UN and the EU as a Middle East Envoy.
He also reportedly earns £250,000 per speech.
Gordon Brown gets a reported £65,000 as an after-dinner speaker and is the United Nations special envoy for education.
Mr Cameron may remain motivated by the public service ideals that drove him into politics, becoming an advocate for a single issue, which would also serve to repair a political legacy badly damaged by the EU referendum result.
If he wants to make money he can go into business knowing he will no longer have to declare the source of his earnings as all MPs must do.
Mr Cameron will also be expected to pen an autobiography or political memoir on his time in Downing Street or perhaps follow other leading politicians into novel writing.
And, of course, there are world lecture forums or the after-dinner circuit that have proven so popularly profitable with his predecessors.
The Liberal Democrat leader has praised Mr Cameron for forming a coalition government but said his main political legacy would be taking the UK out of Europe to the "huge detriment of future generations".
Tim Farron said that the former prime minister had "demonstrated a capacity to think above and beyond tribal politics" by creating the first post-war coalition government between 2010 and 2015.
He also praised Mr Cameron's qualities of "personal courtesy, humour and thoughtfulness" but said the former leader would be mainly remembered for taking the UK out of the EU in a damaging "gamble".
He has lots of things that he should be proud of but sadly his legacy will be one of accidentally removing us from our closest friends and neighbours in Europe.
He took a politically motivated and short-termist gamble with our country's future, and lost to the huge detriment of future generations. He now leaves the rest of us to pick up the pieces.
Theresa May has said she was "proud " to work in David Cameron's government as she thanked him for his service to the country.
The new prime minister said that the Conservatives had achieved "great things" under her predecessor as he resigned from parliament.
I was proud to serve in David Cameron’s Government – and under his leadership we achieved great things. Not just stabilising the economy, but also making great strides in delivering serious social reform.
His commitment to lead a one nation Government is one that I will continue – and I thank him for everything he has done for the Conservative party and the country.
I wish him and his family well for the future.
David Cameron has told ITV News he has no plans for the future after resigning as an MP.
ITV News Deputy Political Editor Chris Ship tweets:
David Cameron told Theresa May of his decision to stand down as a Tory MP this afternoon
David Cameron says he has no current plans for his future but, as former Prime Minister, can't be full constituency MP for people of Witney
Our new Prime Minister has overcome some tough challenges on her way to the top. Theresa May became Home Secretary six years ago where she earned a reputation for being quiet, determined and unflappable.
So how will the challenges she faced as Secretary of State help her in her new role - and how will her past experience help her premiership?
Mrs May's Cabinet appointments dominated the front pages, with many papers leading on Boris Johnson's unveiling as foreign secretary.Read the full story ›
The health watchdog said 1.7 million may have undiagnosed heart or lung conditions.Read the full story ›
Britain's new Prime Minister is expected to spend her first full day in office to continue to form her new government.Read the full story ›
It's been 37 years since Margaret Thatcher walked in to 10 Downing Street, but Theresa May is set to make her own mark on history.
Mrs May looks set to appoint a record number of women in her Cabinet later this week.
ITV News correspondent Juliet Bremner reports: