Along with the first passengers flying to Moscow for a city break, there are also representatives from a dozen companies onboard who are taking part in a trade mission to the Russian capital.
easyJet Chief Executive, Carolyn McCall, a graduate of Kent University in Canterbury, told ITV News why the route is important to her company and to the UK balance sheet.
The new London Gatwick to Moscow service is easyJet's 100th route from the airport in West Sussex. The expansion into Russia is possible after the airline successfully bid for routes that came available when BMI was bought by BA's parent company.
Under a bilateral agreement between the UK and Russia only two airlines from each country between the two capitals. easyJet beat Virgin Atlantic Airways in getting permission to fly the route.
This is the first time Moscow has been served from London Gatwick airport with the airline expecting to fly more than a quarter of a million passengers between London Gatwick and Moscow annually.
The twice daily flights depart London Gatwick at 07:00 and 14:10 each day.The flights are four hours long.