Notts County moved off the bottom with their first win of the season, goals from Joss Labadie and Marcus Haber giving them a 2-0 home win over Tranmere.
County's success saw Gillingham slide to the foot of the table after the winless Gills fell to Gary Jones' ninth minute winner for Bradford at Priestfield Stadium.
Nile Ranger lashed home an 87th minute winner as Swindon left Bristol City still searching for a first win of their own with a 3-2 win at the County Ground. Full match coverage on the ITV Sport website here
Middlesbrough's Tony Mowbray watched his side fight back from the dead against Bournemouth at the Riverside Stadium only to squander their chances of victory.
Two Brett Pitman penalties gave the Cherries a 2-0 lead inside 12 minutes but Kei Kamara and Mustapha Carayol dragged Boro back level.
Grant Leadbitter gave the home side the lead in the 75th minute but a Jonathan Woodgate own goal sealed a point for the visitors seven minutes from time - and to add to Mowbray's woes Rhys Williams was sent off late for a foul on Wes Thomas
Ritchie Humphreys' first goal of the season was enough to maintain Chesterfield's four-point lead at the top of Sky Bet League Two with a hard-fought 1-0 win at Oxford.
Wanderers had taken a first-half lead after Seagulls winger David Lopez put through his own net, but four second-half minutes saw Brighton score three times to leave Dougie Freedman's men still without a win this season.
Jay Spearing put through his own goal in the 53rd minute, before Inigo Calderon and Will Buckley both found the net to stretch the Amex club's unbeaten run to six matches.
David Ngog failed to keep his cool when one-on-one with keeper Tomasz Kuszczak, who made a save down low to deny the French striker after a mix-up in the Brighton defence.
The Croatia international struck in the 54th minute to end Liverpool's 12-match unbeaten league run spanning this season and last.
However, the Saints - the last team to defeat the Reds in March - may not have won 1-0 had referee Neil Swarbrick had the benefit of television replays which showed the defender had brought down Daniel Sturridge in the first half.
Southampton had probed in the first half without properly testing goalkeeper Simon Mignolet, who created his own problems by coming for a ball Skrtel had covered and could only watch as Adam Lallana volleyed over the open goal.
Chances seemed to be a premium for strikers at both ends as Southampton's England international Rickie Lambert had one sight of goal, from Gerrard's miscontrol, but sliced a gentle looping shot into the arms of Mignolet.
Raheem Sterling's came on for Aspas at half-time and should have injected some life into Liverpool's attack but it was Saints who struck in the 54th minute.
Lovren beat Agger to Lallana's corner to head down and past Gerrard on the goalline. It was a goal you sensed had been coming for a while.
Full coverage of all today's fixtures can be found on the ITV Sport website here
Reading had won nine of their previous 11 games against Derby but came into the match with seven first-teamers missing, which meant a first league start for 19-year-old Jordan Obita.
The Royals had not conceded in 285 minutes of Championship football but their defence was almost breached in the eighth minute when Johnny Russell got in on the left and Alex McCarthy could only push out his low shot but Craig Bryson could not turn in the rebound.
The Russian striker found the net for the first time since January and although Will Hughes gave Derby hope, sub Nick Blackman secured Reading's 10th win in 12 games against Derby who have yet to record a home Sky Bet Championship victory this season.
Reading keeper Alex McCarthy kept the visitors in the game in the first half but Pogrebnyak pounced in the 47th minute after a free-kick was knocked down and the side-footed his second in the 62nd minute when Derby failed to clear a cross.
Hughes beat McCarthy with a curling shot in the 80th minute which was the first goal Reading had conceded in 365 minutes of Championship football but Blackman wrapped up the points in the fifth minute of stoppage time.