Deaths involving legal highs have risen with men in their twenties at most risk, according to the Office for National Statistics.
The so-called 'legal highs' are defined in this analysis as new psychoactive substances not controlled under the Misuse of Drugs Act 1971 on the day the person died, such as mephedrone.
However the number is small compared to illegal drugs such as heroin and morphine.
Three teenage boys became critically ill when they took legal highs in Salisbury.
The fifteen year-olds were found in Queen Elizabeth Gardens on Friday - one of them was in a life threatening condition.
All three are now recovering but police say they are investigating.
ITV Meridian spoke to Jeremy Sare from the Angelus Foundation.
Three 15 year old boys needed hospital treatment after taking what are thought to be 'legal highs' in Queen Elizabeth Gardens in Salisbury.
The boys were critically ill and one was considered to be in a life threatening condition at Salisbury District Hospital after the incident on Friday afternoon.
Fortunately all three are now recovering.
Sussex Police have seized a haul of ‘legal high’ substances worth £45,000 from a West Sussex industrial estate.
Officers initially visited the Southwick unit on another matter when they say they discovered five kilograms of drugs.
West Sussex County Council Trading Standards believe the substances were being made on the premises and would have been distributed across the UK.
A 23-year-old woman from Tunbridge Wells wants to make sure people know the dangers of legal highs by sharing her own experiences,
Serena Christie used the substances which have some of the same effects as illegal drugs like cocaine and ecstasy. She also worked in a shop that sold them.
But what happened to her, physically and mentally, was enough to convince her she had to make sure other youngsters know the dangers.
With the help of Fixers - who work with young people on campaigns they feel passionate about - she made this film.
The mother of a student from Brighton who died after taking the then legal high 'GBL' has welcomed the news that the government has banned 500 more new drugs.
Maryon Stewart launched her high profile campaign calling for tougher measures to combat the use of legal highs after her 21-year-old daughter Hester died in 2009.
The bereaved mother founded the Angelus Foundation which works to raise awareness of the potential dangers of so-called legal highs.
Police in Southampton are investigating after concerns have been raised about the use of new psychoactive substances, also known as 'legal highs', in the city. Officers are aware of some cases where medical attention was required on Thursday, April 23.
Members of the public are urged not to consume these products.
Police are working with partners to tackle the use of new psychoactive substances. Anyone who thinks they could be affected by the issues surrounding ‘legal high’ drugs is encouraged to seek professional advice and help:
If you are concerned with your, or anyone else’s drug use, whatever the drug, contact your local drug service, in confidence.
Details of your local drug service can be found at: www3.hants.gov.uk/adult-services/adultservices-professionals/hampshire-daat/treatment-services.htm
A coroner has recorded a verdict of accidental death after a teenager died when he took a legal high. Adam Hunt, who was 18, died at Southampton General Hospital in August. He had taken the drug AMT, which he told a friend he had bought online. After the verdict, his family said,