Police have confirmed that a 35-year-old man from Newhaven died at the scene of the collision.
The collision happened near the junction with the A26 New Road and the B2109 Avis Road at South Heighton just after 10am.
A 65-year-old man from Bishopstone was taken to the Royal Sussex County Hospital in Brighton with serious injuries.
Both men were pedestrians.
The driver of the red dropside DAF lorry, a man from Kent, was uninjured. He was driving south on the A26 when the incident occurred.
Both the A26 and B2109 roads remain closed while investigation and recovery work takes place. It is hoped that the scene will be clear and reopened by mid-afternoon.
Anyone who witnessed the incident is asked to email firstname.lastname@example.org or call 101 quoting Operation Glinsk.
Police have confirmed that one pedestrian has died after being hit by a lorry in Newhaven in Sussex.
Another pedestrian has been taken to hospital.
Two pedestrians have been seriously injured following a collision with a lorry in Newhaven on Friday morning.
Emergency services are attending the scene at South Heighton at the junction of the B2109 Avis Road and A26 New Road where the incident occurred at 10.03am.The road is closed and there are likely to be severe delays in the area while the incident is dealt with. An air ambulance has arrived at the scene.
A lorry carrying bags of cement has crashed into a back garden in Sussex.
The incident happened in Castle Down Avenue in Hastings this morning.
The lorry was delivering bags of cement to a nearby building site when it toppled over with its load into the garden.
The landlord of a pub - badly damaged by a lorry - has called for the speed limit in the area to be reduced. The driver was airlifted to hospital after the crash at the Rising Sun in Woolhampton yesterday. The landlord said it was an accident waiting to happen.
Video report: An articulated lorry has crashed into a 17th century pub in Berkshire, only just missing customers inside. The driver was airlifted to hospital after being cut free from the vehicle which jack-knifed into the Rising Sun pub in Woolhampton at lunchtime today. Kate Bunkall reports
Video: Diners at the Rising Sun in Woolhampton, Berkshire, were enjoying their meals when a lorry crashed into the pub. This couple describe what happened.
VIDEO: A Berkshire pub has been damaged after a lorry crashed into it. The incident vehicle crashed into the Rising Sun in Woolhampton. People inside the pub were unhurt.
A Berkshire pub has been damaged after a lorry crashed into it.
The incident happened a short time ago at the Rising Sun in Woolhampton.
The A4 Bath Road is closed due to the accident