The M4 has been closed eastbound between Junctions 10 and 8 after a multiple pile-up.
There are no reports yet on the seriousness of the injuries.
Highways England have tweeted a picture of the accident:
A few minutes later they tweeted this:
The M4 Westbound Junction 13 to 14 is currently closed following an crash involving two HGV lorries.
All lanes Westbound between junction 13 at Chievely and 14 at Hungerford heading away from London are closed and a diversion is taking motorists off the carriageway at Junction 13.
It is likely to be closed for sometime for recovery. The Eastbound carriageway is currently full open.
The Government has approved an £860m scheme to remove the hard shoulder on the M4 and turn it into a running lane in Berkshire.
The decision was revealed by campaigners tonight following a letter sent to them by the Department for Transport.
It will be the biggest and most expensive road scheme the region has seen.
The entire section between Hayes, near Heathrow and junction 12 at Theale will be converted - the longest section of so-called Smart Motorway in the country.
The Government say it will reduce congestion. But campaigners have expressed anger.
The family of a lorry who died in a crash on the M4 near Reading have paid tribute to him.
Graham Elliott, who was 49 years old and from Dagenham, was killed when his truck overturned on the motorway.
It happened at around 4.50am on Wednesday 11th May 2016, between junctions 12-11 of the M4.
Drivers using the M4 near Reading are being warned of roadworks which will close the motorway for three nights from Wednesday.
A new bridge is being installed over the road as part of the construction of the new Shinfield Eastern Relief Road.
Diversions will be in place from 9pm until 6am.
One lane blocked and slow traffic due to broken down lorry on M4 London bound before J13 A34 (Chieveley / Newbury).
One lane closed and queueing traffic due to broken down lorry on M4 London bound between J14 A338 (Hungerford) and J13 A34 (Chieveley / Newbury).
M4 Westbound lane closed on exit slip road due to broken down car at J15 A346 Marlborough Road / A419 Marlborough Road (Swindon East).
Reports of one lane blocked and very slow traffic due to broken down vehicle on M4 Westbound at J10 A329(M) Wokingham / Bracknell.