It can kill in hours - and leave survivors with devastating after effects.
A campaigner from Sussex who had both lower legs amputated after contracting Meningitis B is urging parents, to take up the new, free vaccine for babies.
Diana Man, who almost died and spent six months in hospital after she was diagnosed - says the UK's new vaccination programme against the commonest form of the disease could change lives.
Our reporter Sarah Saunders went to Uckfield to meet her.
The Coneybeare family from Caversham are backing a national campaign for a new vaccine, after their daughter, Eleanor, lost her leg to meningitis.
They are supporting the Beat it Now campaign to ask the Government to introduce a new vaccine against Meningitis B - one of the deadliest forms of the disease - available to all children.
The new drug, Bexsero, is the first of its kind and received it licence for use in the UK in January. They also have the support of their MP, Rob Wilson (Con).