In League One, Oxford United start their campaign without captain John Lundstram, who's departed for Sheffield United.
But the U's have a new boss, with a distinctly Spanish flavour.
As Cary Johnston reports.
Cary spoke to Oxford United Manager, Pep Clotet.
Oxford's Wembley dream came to an end a short while ago - after a 2-1 defeat to Coventry City. Thirty thousand fans travelled up to the capital to cheer on the Us in the final of the Checkeatrade Trophy. Earlier in the day a convoy of coaches left the Kassam stadium - with high hopes. Our reporter Mary Stanley was there.
Oxford United's hearts were broken at the Riverside when they were knocked out of the FA Cup yesterday.
Christhian Stuani earned Middlesbrough a 3-2 win in a storming FA Cup fifth round tie. The U's had come back from two goals down after trailing to a Grant Leadbitter penalty and a Rudy Gestede volley.
Oxford United Football Club's players could secure promotion from League Two if they win at Carlisle on Saturday and other results go their way.
The football club has two league matches remaining and if the side wins both, the players will definitely secure promotion. But if results go badly, Bristol Rovers and Plymouth are among the clubs hoping to exploit any slips. Chris Maughan spoke to the U's manager Michael Appleton before the team set off for Carlisle.
Oxford United have begun their search for a new manager after Chris Wilder this morning took up the top job at fellow League Two side Northampton Town.
The Cobblers sit at the bottom of League Two, 23 points behind sixth place Oxford. Wilder, whose last game in charge was Saturday's one nil win over Torquay, has managed the U's since 2008 - winning promotion back to the Football League two years later. He says this move was a difficult decision.
Chairman Ian Lenagan has released this statement about the resignation of Oxford United Manager Chris Wilder:
Oxford United manager Chris Wilder has resigned.
He formally handed in his termination yesterday, which was accepted by the Board.
Assistant Manager, Mickey Lewis, has agreed to become Caretaker Manager and will be in charge when Oxford play Exeter City tomorrow night.