he Birmingham goalkeeper was beaten again in the 75th minute. Dan Burn fouled Robson-Kanu on the edge of the area and Guthrie curled home a fine free-kick via Randolph's near post to complete** **Reading's comfortable win.
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Birmingham failed to capitalise on their early superiority and Reading responded with a series of swift breaks. Garath McCleary released Pavel Pogrebnyak inside the Birmingham area but the Russian's fierce shot was well saved by Darren Randolph.
Reading's pressure finally paid off in the 32nd minute as they took the lead, albeit with a goal that was tinged with good fortune.
Chris Burke was penalised for handball and Guthrie's free-kick from wide on the left did not appear to carry too much danger. Yet it somehow found its way through a mass of bodies in the area and nestled in the far corner of Randolph's net.
Martyn Woolford drove the Lions ahead shortly after the break and the visitors had Alan Dunne sent off for two bookable offences before Ulloa struck a minute from time.
Millwall settled quickly and Brighton's Spanish defender Inigo Calderon put a Dunne cross behind for the first corner of the match before a goal-bound header from Woolford was saved by goalkeeper Tomasz Kuszczak.
Brighton's Dutch midfielder Kemy Agustien drove wide from the edge of the area in the 16th minute after the ball was squared to him by Rohan Ince.
The Seagulls went into the game with Argentinian Ulloa as their only fit striker.
In the first ever league meeting between the sides, Adam Le Fondre's penalty 13 minutes from time handed the Royals their first Sky Bet Championship win since the opening day - and condemned the Glovers to a fifth consecutive defeat in all competitions.
Reading manager Nigel Adkins made sweeping changes after the Royals' 6-0 humiliation at Peterborough United - with only Chris Gunter, Shaun Cummings and Le Fondre surviving the cull.
Adkins swapped Gareth McCleary for Danny Williams in a surprise first-half substitution and the newly-introduced midfielder came closest for the Royals before the break when he volleyed former Real Madrid and Everton winger Royston Drenthe's deep cross wide of the post.
The game exploded into life in the second half and Grabban's strike partner Pitman should have made it two when he was awarded a penalty by referee Graham Scott after being brought down by Stephen Crainey.
But former England stopper Carson guessed correctly down to his right and ensured the Cherries top scorer from last year would not get on the score-sheet on his return to the starting line-up.
Grabban scored in the 43rd minute before the Cherries squandered the chance to go two goals clear when Brett Pitman missed a penalty 10 minutes after half-time.
The Latics' task became harder just minutes later when substitute Callum McManaman was sent off just three minutes after coming on.
Bournemouth boss Eddie Howe started at right-back the last time the Cherries beat Wigan in the league 12 years ago.
It took Wigan two attempts to beat the Cherries on their way to FA Cup victory last season and James McCarthy came close to opening the scoring after seven minutes when his dipping 25-yard effort was tipped over the bar by Ryan Allsop.