he Birmingham goalkeeper was beaten again in the 75th minute. Dan Burn fouled Robson-Kanu on the edge of the area and Guthrie curled home a fine free-kick via Randolph's near post to complete** **Reading's comfortable win.
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Birmingham failed to capitalise on their early superiority and Reading responded with a series of swift breaks. Garath McCleary released Pavel Pogrebnyak inside the Birmingham area but the Russian's fierce shot was well saved by Darren Randolph.
Reading's pressure finally paid off in the 32nd minute as they took the lead, albeit with a goal that was tinged with good fortune.
Chris Burke was penalised for handball and Guthrie's free-kick from wide on the left did not appear to carry too much danger. Yet it somehow found its way through a mass of bodies in the area and nestled in the far corner of Randolph's net.
Both of Guthrie's goals come from free-kicks - the first unintended, as it flew through a packed Birmingham penalty area, and the second an accurate set-piece that found the net via a post.
Those goals helped Reading make it 13 points from their last five league games and leave Birmingham unable to cap a memorable week with a third successive victory.
Lee Clark's men beat Sheffield Wednesday 4-1 in the league last time out and then followed that up with a 3-1 cup win over Swansea, and buoyed by those successes they started brightly.
Millwall were reduced to ten men 14 minutes from time when Dunne received his second yellow card for bringing down Orlandi.
Orlandi had a superb shot from the edge of the box tipped over by Forde before Ulloa rescued a point for Brighton at the far post from a cross by LuaLua.
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Millwall did a good job of stifling Brighton in the first half and Shittu was there to clear a dangerous low cross by Will Buckley shortly before the break.
The Lions had David Forde back in goal and the Irishman was not tested in the opening period.
Millwall broke the deadlock after 51 minutes through Woolford who calmly slotted home from close in after being set up by Richard Chaplow.
Brighton boss Oscar Garcia, having introduced Andrea Orlandi for Agustien at the break, threw on Kazenga LuaLua in place of David Lopez, and the winger twice had shots deflected wide.
Martyn Woolford drove the Lions ahead shortly after the break and the visitors had Alan Dunne sent off for two bookable offences before Ulloa struck a minute from time.
Millwall settled quickly and Brighton's Spanish defender Inigo Calderon put a Dunne cross behind for the first corner of the match before a goal-bound header from Woolford was saved by goalkeeper Tomasz Kuszczak.
Brighton's Dutch midfielder Kemy Agustien drove wide from the edge of the area in the 16th minute after the ball was squared to him by Rohan Ince.
The Seagulls went into the game with Argentinian Ulloa as their only fit striker.
Yeovil again dictated proceedings at the start of the second half, with on-loan striker Andy Williams coming inches away from breaking the deadlock after hitting a curling effort narrowly wide.
However, Huish Park once again became the centre of controversy on 77 minutes after referee Trevor Kettle awarded the Royals a penalty after Luke Ayling was adjudged to have brought down Le Fondre.
The striker picked himself up and slammed past goalkeeper Wayne Hennessey to net his third league goal of the season and earn the visitors the valuable three points
In the first ever league meeting between the sides, Adam Le Fondre's penalty 13 minutes from time handed the Royals their first Sky Bet Championship win since the opening day - and condemned the Glovers to a fifth consecutive defeat in all competitions.
Reading manager Nigel Adkins made sweeping changes after the Royals' 6-0 humiliation at Peterborough United - with only Chris Gunter, Shaun Cummings and Le Fondre surviving the cull.
Adkins swapped Gareth McCleary for Danny Williams in a surprise first-half substitution and the newly-introduced midfielder came closest for the Royals before the break when he volleyed former Real Madrid and Everton winger Royston Drenthe's deep cross wide of the post.