Kent Police are concerned about two 16-year-old girls last seen on 23 March at their homes in Northfleet in Kent.
Natalie Kelly and Rosina Lee are believed to be travelling to London to meet men they may have met on the internet.
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The A27 will remain closed in both directions near Lewes during rush hour due to a large fire at a recycling plant.
Friday morning's forecast for the east of the region
Friday morning's forecast for the west of the region