The M2 near Gillingham in Kent has been closed in both directions following a serious crash between a lorry and a car.
The motorway was shut to allow the Kent Air Ambulance to land.
Police say the road is not expected to be fully reopened until at least 4pm.
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The A27 will remain closed in both directions near Lewes during rush hour due to a large fire at a recycling plant.
Friday morning's forecast for the east of the region
Friday morning's forecast for the west of the region