Four lorries have been involved in a multiple collision on the coastbound section of the M20 near junction 10, which occurred around midnight last night.
Two lorry drivers have been taken to the William Harvey Hospital with serious injuries.
The section between junctions 9 and 10 is expected to remain closed until after lunchtime while the investigation continues and the lorries and debris are cleared from the scene. A diversion is in place.
Anyone who witnessed the incident is asked to contact Kent Police on 01622 798538.
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The M20 London bound carriageway has now been reopened to traffic but Operation Stack is expected to remain in place into the weekend.
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Friday morning's forecast for the west of the region