Operation Fortress is aiming to make Southampton a hostile environment for drug dealers.
Since its launch in May, the two year campaign to combat drug-related violence has seen more than 150 arrests and £150,000 worth of drugs and cash taken off the streets.
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Tuesday's weather for the west of the region
Tuesday's weather for the east of the region
A further 85 buses are expected to arrive on Tuesday and Wednesday, with officials saying the entire operation will last at least a week.