Thames Valley Police is appealing for witnesses to a fatal collision this morning.
At about 5.50am, a red motorbike travelling towards Reading and a black Audi A4 travelling in the opposite direction collided on the A4074 near Ipsden.
The motorcyclist, a man in his twenties, died at the scene.
The road was closed for several hours in both directions while investigations were carried out - and has only just been reopened.
Anyone who saw the collision or the vehicles prior to the incident is asked to call PC Sarah Davies on 101 or Crimestoppers anonymously on 0800 555111.
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