Along with the first passengers flying to Moscow for a city break, there are also representatives from a dozen companies onboard who are taking part in a trade mission to the Russian capital.
easyJet Chief Executive, Carolyn McCall, a graduate of Kent University in Canterbury, told ITV News why the route is important to her company and to the UK balance sheet.
This is a historic day for easyJet, not only are we launching flights between London Gatwick and Moscow but it is also the first day our shares are traded on the FTSE 100. Russia is the world’s largest country with a growing economy. Offering frequent and affordable flights enables easyJet to play a key role to aid trade links between the two countries.
I am pleased to have around a dozen UK companies travelling with us today aiming to start to build relationships in Russia. These companies are spread across Britain and represent many sectors including food, technology and manufacturing.
More top news
Wednesday's weather for the west of the region
Wednesday's weather for the east of the region
Wednesday morning's forecast for the east of the region