Crystal Watts and Chelsea Hutt, both aged 15 from Blackbird Leys, were last seen on Thursday at their homes.
Crystal is slim, around 5ft and has highlighted hair. Chelsea is around 5ft 5ins, with shoulder length dark brown hair. She was last seen wearing a black and white coat with a fur hood, a grey hooded jumper with a brown handbag and a coloured bag on her back.
More top news
Wednesday morning's weather for the west of the region
Wednesday morning's weather for the east of the region
The Transport Select Committee says the government needs to demonstrate that a lorry park will be the best solution for Operation Stack.