Crystal Watts and Chelsea Hutt, both aged 15 from Blackbird Leys, were last seen on Thursday at their homes.
Crystal is slim, around 5ft and has highlighted hair. Chelsea is around 5ft 5ins, with shoulder length dark brown hair. She was last seen wearing a black and white coat with a fur hood, a grey hooded jumper with a brown handbag and a coloured bag on her back.
More top news
Windsor-based Centrica, the parent company of British Gas, is cutting six thousand jobs.
Thursday afternoon's weather for the east of the region
Thursday afternoon's weather for the west of the region