The pollen count will increase as temperatures heat up and the worst conditions are expected on Sunday and Monday, according to forecasters.
Alexander Burkill, of the Met Office, said tree pollen would be more significant than grass pollen until the middle of May.
He said the tree pollen count will be high towards the end of the weekend, adding: "Today we've got a fair bit of cloud and the rain coming down, so it's going to go down to moderate.
Today and Monday in places, especially across England and especially in the south east, you're looking that it could get up to high."
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Monday afternoon's forecast for the east of the region
Monday afternoon's forecast for the west of the region
Monday's forecast for the east of the region