The Sky Blues, who start the new campaign with a 10-point deduction, had looked to have salvaged a point when second-half goals from Callum Wilson and Franck Moussa saw them cancel out early efforts from Jamie Proctor and Joe Walsh
However, the visitors were left empty-handed when Mike Jones netted an 84th-minute winner for Crawley Town at the Broadfield Stadium in West Sussex.
For a full round-up of all today's action click here for in-depth match coverage from ITV Sport
More top news
Oxford's most famous hotel, the Randolph, is ablaze after a fire started in the roof space. 12 fire crews are on location in the city.
Friday night's weather for the east of the region
Friday night's weather for the west of the region