The A325 in Surrey is closed both ways due to a serious accident between B3207 Water Lane and B3007 Hale Road (Six Bells Roundabout).
An air ambulance is attending the scene and the road is closed in both directions.
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Police are appealing for help to try and find a woman who has gone missing along with her six-year-old daughter.
Friday's forecast for the east of the region
Friday's forecast for the west of the region