Wanderers had taken a first-half lead after Seagulls winger David Lopez put through his own net, but four second-half minutes saw Brighton score three times to leave Dougie Freedman's men still without a win this season.
Jay Spearing put through his own goal in the 53rd minute, before Inigo Calderon and Will Buckley both found the net to stretch the Amex club's unbeaten run to six matches.
David Ngog failed to keep his cool when one-on-one with keeper Tomasz Kuszczak, who made a save down low to deny the French striker after a mix-up in the Brighton defence.
More top news
A man has been taken to hospital with serious injuries after being beaten by a gang of 10 in the early hours of this morning.
Southern Railway said it expects to run three quarters of its normal service during a fresh 24-hour strike by some of its staff next week.
It's not often you get the chance to sunbathe in February, but crowds swarmed to Brighton beach yesterday. A few tops even came off!