Wanderers had taken a first-half lead after Seagulls winger David Lopez put through his own net, but four second-half minutes saw Brighton score three times to leave Dougie Freedman's men still without a win this season.
Jay Spearing put through his own goal in the 53rd minute, before Inigo Calderon and Will Buckley both found the net to stretch the Amex club's unbeaten run to six matches.
David Ngog failed to keep his cool when one-on-one with keeper Tomasz Kuszczak, who made a save down low to deny the French striker after a mix-up in the Brighton defence.
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Wednesday evening's weather for the west of the region
Wednesday evening's weather for the east of the region