Staff at universities, including Brighton, Sussex and Southampton Solent, will be going on strike today in a row over pay.
Members of Unison and Unite will be forming picket lines from 7am.
It is their first national strike over pay in 7 years.
The strikes could mean that lectures or tutorials are cancelled, possibly causing disruption to whole departments.
The strikes are predicted to have a "low level impact" on students.
More top news
Increasingly cloudy with drizzly rain tonight. A cloudy start on Monday but brightening up with plenty of sunny spells in the afternoon.
The grass pollen risk will rise to high during warm, dry weather.
Cloudy with patchy rain and drizzle this evening. Mild tonight, then dry with plenty of sunny spells tomorrow.