Staff at universities, including Brighton, Sussex and Southampton Solent, will be going on strike today in a row over pay.
Members of Unison and Unite will be forming picket lines from 7am.
It is their first national strike over pay in 7 years.
The strikes could mean that lectures or tutorials are cancelled, possibly causing disruption to whole departments.
The strikes are predicted to have a "low level impact" on students.
More top news
The grass pollen risk will be very high during warm, sunny weather. Weed pollen will also be airborne
Dry and sunny with long spells of sunshine in the south east and feeling hot
Fine and dry with some good long sunny spells, especially this afternoon and early evening and feeling very warm