Southampton FC have confirmed the resignation of Executive Chairman Nicola Cortese, in a statement on the club's Twitter feed.
Owner Katharina Liebherr has taken on the role of non-executive chairman.
A statement on the club website says a search has begun for a Chief Executive Officer who will take over Mr Cortese's executive duties.
More top news
A GP in Surrey has launched a petition calling for a £90m fine handed to two drugs companies, to be reinvested in the NHS and epilepsy care.
Friday evening's weather update for the east
Friday evening's weather update for the west