Long tailbacks built up after the M2 in north Kent was shut at Lynsted, between junction 5 near Sittingbourne and junction 6 south of Faversham.
The Highways Agency said the hole measured 16ft (5m) by 6ft (2m) and was 50ft (15m) deep.
A spokeswoman said: "The road has been closed while urgent safety checks are made following a large hole opening up in the central reservation.
"Agency staff and contractors are working hard to inspect the hole and make the necessary repairs and lanes will be reopened when it is safe to do so."
She added that there were delays both east and westbound in the area of the closure and urged drivers heading to and from the port of Dover to use the M20 instead.
More top news
Supporters arriving in Nizhny Novgorod praised the atmosphere in the city.
Headliners taking to the stage during the weekend will be Kasabian, Depeche Mode, Liam Gallagher and The Killers.
The ants gave England their backing when the insect carrying the England flag beat the one carrying Panama's flag back to the queen.