Amanda Chalmers was born with cystic fibrosis and will run the Brighton Marathon less than two years after undergoing a double lung transplant.
The 26-year-old University of Brighton graduate could hardly walk up the stairs before her life-saving operation in September 2012. She'll be raising money for the Cystic Fibrosis Trust.
We caught up with her while training in nearby Preston Park. You can sponsor her here.
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Direct rail services between Southampton and Brighton will be disrupted until the end of this week.
Wednesday morning's weather for the west of the region
Wednesday morning's weather for the east of the region