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Tony Nicklinson is distraught after losing his High Court battle for a doctor to end his life, legally, at a time of his choosing.
ITV News's Emily Morgan was with the family when they heard the news. He signalled that the news was "devasting". He communicates via his wife and a series of blinks.
The judges ruled that, however understandable the motives may be, any change to the law on assisted dying was a matter for Parliament and not the courts..
Mr Nicklinson describes his life as "pure torture - undignified and intolerable". He was left paralysed below the neck by a stroke.
Professor John Saunders, chairman of the Royal College of Physicians ethics committee, said:
Lawyer Yogi Amin, from Irwin Mitchell, said it was up to Parliament to decide the next steps. He said that, "the law on this sensitive and emotive issue is very clear at present - physician-assisted suicide is unlawful."
Pro-life campaigners have welcomed the judges' decision to reject the challenge by two locked-in syndrome sufferers for the legal right to end their life with the help of a doctor.
Sarah Wootton, chief executive of Dignity in dying, has said that she was "not surprised" by Tony Nicklinson's case failing in the High Court.
Saimo Chahal, a partner with Mr Nicklinson's solicitors Bindmans LLP, said the next stage of the case would be to prepare an application to appeal against the decision.
She said she would be asking for the case to be expedited so that it can be heard by the Court of Appeal as soon as possible.
Ms Chahal added that Mr Nicklinson's health had deteriorated recently and he was in a great deal of physical pain and discomfort.
She confirmed that he was not prepared to give up his fight to establish the principle of being able to die with dignity when he chooses.
The second man whose right-to-die case was heard by the High Court, referred to as "Martin", 47, has responded to losing his challenge to the legal ban on assisted dying:
Paul Bowen QC, representing Mr Nicklinson, confirmed - as expected - an appeal will be made after the High Court denied his right to have a doctor end his life.
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The Courts have left it up to Parliament -so what next for the right to die issue?
Tony Nicklinson, who was left paralysed by a catastrophic stroke, has lost his High Court battle to have a doctor end his life.