Egyptian President Mohammed Morsi has said that those responsible for a train crashing into a school bus near the city of Assiut will be held accountable.
Morsi appeared on state television, saying "those responsible for this accident will be held accountable", and promising financial compensation for victims' families.
The transport minister and head of Egypt's railways have resigned.
At least 50 children, some as young as four, were killed after their school bus was hit by a train in Egypt.
The crash happened on a rail crossing in a city south of Cairo.
Two adults, thought to be the bus driver and a teacher, also died.
ITV News' Damon Green reports.
The death toll after a train crashed into a school bus in Egypt, has now risen to 50.This news comes as Prime Minister Hisham Kandil travelled to the area.
Pictures from Associated Press and footage from a mobile device.
Mohamed Samir, a doctor at Assiut hospital where the injured were taken, cited witness accounts when he said: "They told us the barriers were open when the bus crossed the tracks and the train collided with it."
Many of the dead bodies were severely mutilated, indicating the force of the crash, which took place in the city of Manfalut, near Assiut, about 300 km (190 miles) south of the capital.
Ahmed Youssef, a driver, said: "I saw the train collide with the bus and push it about one km (half a mile) along the track.
A senior security official near the crash site in Assiut said 44 of the dead were children, aged around four to eight.
Two women and a man, who was probably the bus driver, also died.
The state news agency said another 13 people were injured, while a medical source said as many as 28 were injured, 27 of them children.
There have been a string of accidents on Egypt's roads and railways, which have a poor safety record.
An Egyptian official has said that 47 school children died in the collision between a bus and a train today.
An official in Egypt has said a rail road crossing was not closed as the train headed towards the bus carrying school children.
Forty school children were killed when a train crashed with a bus south of Egypt's capital on Saturday, according to the official state news agency.
The train reportedly hit the school bus from the city of Manfalut, near Assiut.
The city's governor has ordered an enquiry into the incident.