The changes which will see the A&E department and maternity services at Lewisham Hospital in south east London both downgraded are part of a shake-up of services in the capital after the financial collapse of a neighbouring NHS trust.
The overhaul was proposed by a special administrator in response to nearby South London Healthcare NHS Trust going into administration after it started losing around £1.3m a week.
The Health Secretary Jeremy Hunt rejected a plan to replace Lewisham's A&E unit with an "urgent care" centre, but accepted the recommendations of a further review by NHS medical director Sir Bruce Keogh that Lewisham should have a "smaller A&E service with 24/7 senior emergency medical cover."
The unit will continue to see up to three-quarters of those currently attending Lewisham A&E.
The closures are part of a radical overhaul proposed by a special administrator in response to nearby South London Healthcare NHS Trust (SLHT) going into administration after it started losing around £1.3 million a week.
Shadow health secretary Andy Burnham warns that if the proposals are implemented it could set a "dangerous precedent" for the rest of the NHS.
"If that were to be approved, I believe it would set a dangerous precedent to the NHS when the NHS is taking out A&E capacity on the basis of finance, not on care and quality, and that is a line over which the Government must not cross," he said.