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Stafford-based campaign group Cure the NHS, which includes relatives of patients affected by poor care and other community members, successfully lobbied the coalition Government for a full public inquiry.
Speaking ahead of Wednesday's report publication, Cure the NHS member Ken Lownds said:
Prime Minister David Cameron is due to meet families of the victims of scandal-hit Stafford Hospital at No 10 Downing Street today.
The meeting takes place before the release of the major report into the disaster during the late 2000s.
A public inquiry into regulators' failure to prevent routine neglect at a scandal-hit NHS hospital must lead to a more "patient-centred" health service, a body representing NHS managers has urged.
The head of the NHS Confederation said Wednesday's publication of a report into Stafford Hospital would rightly expose failings which led to what a previous independent inquiry described as "appalling" standards of care.
The confederation's chief executive, Mike Farrar, pledged that NHS leaders would respond positively to the report and work to change the culture of the NHS.
Predicting that the release of the report would be "one of the darkest days" in the history of the NHS, Mr Farrar acknowledged that changes needed to be made to make patient feedback easier and give the public a clearer picture of how local services were performing.
He said: "Our failings in Mid Staffordshire will be laid bare - and rightly so.
"The people in charge of running our health services should rightly be held to account when they fail to act in the interests of patients."