A car bomb exploded outside a mosque in Karachi, Pakistan, killed at least 45 people and wounded more than 149, a senior official told the Associated Press.
No one has taken responsibility for the bombing, that took place outside a Shiite mosque as people were leaving evening prayers in Pakistan's largest city.
Initial reports suggested the bomb was rigged to a motorcycle, but a police official told the Associated Press that an estimated 220 pounds of explosives was planted in a car.
A suspected suicide bombing outside a Shiite mosque in Pakistan's commercial capital Karachi has claimed the lives of 45 people and wounded 149, senior city official Hashim Raza has said.
The attack is the latest signal that Sunni groups are escalating sectarian bombings against the minority.
The bombing in the Shiite area of Karachi has killed 25 people and wounded 50, Pakistani police have told Reuters.
Seven people have been killed in a bomb blast in the Shiite Muslim area of Karachi in southern Pakistan, officials have said.